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| Region 4 | Region Record | Region % | Overall Record | Overall % |
| Monterey | 2-0 | 1.000 | 5-0 | 1.000 |
| Clay County | 2-0 | 1.000 | 5-0 | 1.000 |
| Gordonsville | 1-1 | .500 | 1-4 | .200 |
| Jo Byrns | 1-1 | .500 | 1-4 | .200 |
| Pickett County | 0-2 | .000 | 1-4 | .200 |
| Red Boiling Springs | 0-2 | .000 | 0-4 | .000 |
Week 5 scores
Clay Co. 35, Gordonsville 6
Jo Byrns 44, Red Boiling Springs 14
Monterey 63, Pickett Co. 16
Week 6 (Sept. 27)
Clay County at Westmoreland
Coalfield at Gordonsville
Jo Byrns at East Robertson
Jackson County at Monterey
Pickett County at Sale Creek
Red Boiling Springs at Oakdale
| Region 5 | Region Record | Region % | Overall Record | Overall % |
| Fayetteville | 3-0 | 1.000 | 5-0 | 1.000 |
| Cornersville | 2-0 | 1.000 | 3-2 | .600 |
| Mt. Pleasant | 1-2 | .333 | 2-2 | .500 |
| Richland | 0-1 | .000 | 3-2 | .600 |
| Huntland | 0-1 | .000 | 2-3 | .400 |
| Moore County | 0-2 | .000 | 2-3 | .400 |
Week 5 scores
Cornersville 20, Mt. Pleasant 0
Fayetteville 27, Moore Co. 14
South Pittsburg 53, Huntland 7
Richland 42, Lookout Valley 6
Week 6 (Sept. 27)
Middle Tennessee Christian at Cornersville
Richland at Fayetteville
Huntland at Lookout Valley
Eagleville at Moore County
Wayne County at Mt. Pleasant
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